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Min JN, Whaley RA, Sharpless NE, Lockyer P, Portbury AL, Patterson C (2008) CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control

doi: 10.1039/D0FO02736G 34

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For instance, patients with chronic intestinal inflammatory diseases, such as inflammatory bowel disease (IBD), often exhibit impaired intestinal barrier function and increased mucosal permeability, which facilitates bacterial translocation (137)