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Overall, although rapid progress has been achieved in this field in recent years, some crucial issues and challenges remain to be solved

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(2010), both MTT and Transwell filter migration assays were used to establish cell proliferation of tendon fibroblasts, along with staining (FITC-phalloidin) and Western blot analysis to determine the protein expression and activation of FAK and paxillin

doi: 10.1016/j.cgh.2009.07.017 108 MatsuokaKNishiumiSYoshidaMKodamaY

The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration

When used together, MTX and the added drugs can attack joint inflammation from multiple, complementary angles, producing a synergistic effect that is more powerful than either drug alone (Friedman & Cronstein, 2019)