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Conversely, both apoB100 and MTTP are negatively regulated by insulin, which reduces hepatic lipid export by inducing apoB100 degradation and suppressing MTTP synthesis [111]

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More importantly, the NMS of GI dysfunction (i.e., constipation) often appears much earlier in PD patients, predating the onset of motor symptoms by as many as 20 years (Abbott et al., 2001

Existing studies simply showed that the reduced gut Lactobacillus abundance in OA patients was associated with iron overload and chondrocyte ferroptosis

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