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Plain Language Summary Vitamin B12 deficiency has long been thought to be associated with dementia and other neurocognitive disorders

Mobile phase A consisted of 0.1 % (v/v) formic acid and mobile phase B consisted of 90% (v/v) acetonitrile and 0.1% (v/v) formic acid

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After a centrifugation at 12,000 g for 15min at 4C, the supernatant was collected, and the protein concentration was measured using a bicinchoninic acid assay

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The capsule has the functions of lowering lipids and anticoagulation, inhibiting platelet adhesion and aggregation, and improving blood rheology (Li and Shi, 2013