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The Lactobacillus rhamnosus produces two soluble proteins, p40 and p75, which prevent cytokine-induced epithelial apoptosis through epidermal growth factor receptor (EGFR) and protein kinase C (PKC)-dependent pathways [95]

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Wu T, Hu Y, Lee Y-T, Bouchard KR, Benechet A, Khanna K, et al

However, in NDDs, this microglia balance is disrupted, and the activation of pro-inflammatory microglia contributes to neuronal damage and synaptic loss [5,6,7]

Both histamine and Hcy require methylation for their metabolism, which suggests that hypomethylation may cause histamine intolerance in MCAS and EDS

These effects are typically short-lived