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D.et al (2019)

Dogs taking the supplement, which provided 225 mg of SAMe and 82 mg of silybin-phosphatidylcholine complex (24 mg of silybin) per day, throughout chemotherapy were less likely to exhibit increased biomarkers of liver damage and were less likely to have their chemotherapy treatments delayed due to increased liver enzyme activity

Interplay between Diet and Gut Microbiome, and Circulating Concentrations of Trimethylamine N-Oxide: Findings from a Longitudinal Cohort of US Men

PubMed PMID: 21699455

In some clinical studies, a lower dose of 37.5 mg twice daily was used to good effect

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