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Increases SIRT-1 activity as a result of enhanced NAD+ salvage, leading to beneficial epigenetic and metabolic reprogramming, including increased oxidative phosphorylation (OXPHOS) and muscle stem cell activation 1-3

Comprehensive preclinical safety evaluations across multiple animal models demonstrate favorable tolerability profiles with excellent safety margins for investigational research applications

In general, though, these injections last about a week or two

There is always a risk of potential side effects when taking medication

Injections ensure your body gets maximum effectiveness compared to oral supplements that may lose potency during digestion

When NNMT activity is elevated as documented in obese adipose tissue, several cancer types, and aged skeletal muscle intracellular NAD+ availability decreases, SAM availability decreases, and downstream sirtuin activity (particularly SIRT1 and SIRT3) is reduced