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Klar AS, Biedermann T, Michalak K, Michalczyk T, Meuli-Simmen C, Scherberich A, Meuli M, Reichmann E

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9 Acquired 5FU resistance is associated with increased mitochondrial content and signaling

doi: 10.1007/s12011-019-02017-6 25

Therefore, the deletion of the GDH2 gene will certainly impact on the catabolism of arginine and proline, considering that Gdh2 is the main enzyme capable of converting glutamate into -ketoglutarate through the reduction of NAD +