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Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats

Principal component analysis (PCA) was performed using the prcomp function in R stats package (v4.2.1)

We found significantly lower mean Tajimas D for the top SNPs from the GWAS compared with background SNPs for three of the four traits (Figure 8) due to an excess of low frequency alleles (i.e., low MAFs), consistent with purifying selection (Paape et al., 2013)

(II) social cognition

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Several studies have demonstrated that metformin can alter the composition of the gut microbiota in both healthy individuals (Forslund et al., 2015