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149 Under specific conditions, ROS can bypass these pathways to induce pyroptosis, driven by inflammasome activation (e.g., NLRP3) in response to PAMPs/DAMPs, the predominance of inflammatory caspases (caspase-1/4/5/11) over caspase-8 or RIPK3, and cell-specific mechanisms prioritizing cytokine release (IL-1/IL-18) in immune cells like macrophages

Understanding the role of the gut microbiome in diabetes and therapeutics targeting leaky gut: A systematic review

doi: 10.12688/f1000research.152917.2

This suggests that supplementation with vitamin K would be beneficial, especially for those with low levels of vitamin K (the standard deviation of vitamin K levels in the autism group was large)