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The increased progesterone release by GCs may be related to increased autophagy of GCs in EMS patients, higher expression of Beclin-1(BECN1), and greater low-density lipoprotein degradation capacity

Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis

Baicalein, another important flavonoid, demonstrates significant cardioprotective effects through activation of the Nrf2 signaling pathway, thereby attenuating the oxidative stress damage caused by tert-butyl hydroperoxide in H9C2 cardiomyocytes

Glutamine mitigates oxidative stress-induced matrix degradation, ferroptosis, and pyroptosis in nucleus pulposus cells via deubiquitinating and stabilizing Nrf2

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This pulsatile nature is considered central to its physiological effectiveness