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The majority of the published studies on nanocarriers (Table III) lack thorough investigation of the capability of the nanocarriers to bind to the targeted transporter and evidence that the nanocarrier endocytosis or transcytosis is mediated by binding to the transporter

Order is always accurate

Furthermore, the mature fiber without organelles lacks the protein synthesis and degradation machinery necessary for removing and replacing damaged proteins (148)

The Winter shunt has historically been a common initial approach after failed irrigation as it is simple to perform, can be done under local anesthetic, and comes with minimal complications [9]

It seems likely that a fuller appreciation of these issues will not only help to understand the molecular basis of some disorders, but will further the development of increasingly sophisticated and targeted therapies (236)