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Shenefelt, P

Rarely reported symptoms associated with excessive B12 intake may include: Skin reactions : Acne-like eruptions or rosacea-type dermatitis have been occasionally reported, particularly with high-dose intramuscular injections Gastrointestinal disturbance : Mild nausea, diarrhoea, or abdominal discomfort, though these are uncommon Headache : Infrequent reports of headaches following parenteral B12 administration Hypersensitivity reactions : In very rare cases, allergic reactions to injectable B12 preparations have been documented It is crucial to note that there is no established link between standard B12 supplementation and serious adverse effects

Construction of bispecific nanobodies To construct the PV2-PV3 recombinant fusion nanobody, a 15-amino acid flexible linker (GGGGS) 3 was selected as the connecting peptide

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622 Although quercetin is poorly absorbed in the intestines, it is digested by gut microbes, producing other compounds that may contribute to its cardio-protective effects

doi: 10.3389/fneur.2020.592514 43 FenwickG