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[15] [18] For borderline results, additional tests such as methylmalonic acid, homocysteine, or holotranscobalamin may be considered

43 ), identical to the effect of Rho-associated coiled-coil containing protein kinase (ROCK) inhibitors 44

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Experimental studies in animal models and study of the mutant proteins in cultured cells suggest that the defective proteins encoded by these genes cause cataracts by interfering with the normal function of lens fiber cells or by promoting their own aggregation and, perhaps, the aggregation of normal lens proteins