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Ischemia-reperfusion significantly increases apoptosis, mitochondrial fission, and autophagic flux 138

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How should CMS consider the discount, sharing rate, and risk corridors or marginal savings bands in the design of a higher risk option that can realize savings for Medicare

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Liang P, Henning SM, Guan J, Grogan T, Elashoff D, Cohen P, Aronson WJ (2020) Effect of dietary omega-3 fatty acids on castrate-resistant prostate cancer and tumor-associated macrophages

Collectively, these compositional shifts implicate multiple functional pathways relevant to CHE, including short-chain fatty acid production (e.g., Lachnospiraceae , Eubacterium ) [72], inflammatory signaling and microbial product-related pathways (e.g., Enterobacteriaceae , Streptococcaceae ) [73], and ammonia or nitrogen metabolism (e.g., Clostridiales ) [74], rather than a single dominant mechanism