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The dose of SFN administered was titrated down and 5mg/kg SFN was found to be sufficient to significantly prolong the survival of artesunate-treated mice infected with 1804 M488I parasites (Fig 8D-E)

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Fedde, KN, Blair, L, Silverstein, J, Coburn, SP, Ryan, LM, Weinstein, RS, Waymire, KG, Narisawa, S, Milln, J-L, MacGregor, GR, and Whyte, MP (1999) Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia

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