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In patients with renal dysfunction, peak concentrations of metabolites 4'-hydroxy- and 5-hydroxy-diclofenac were approximately 50% and 4% of the parent compound after single oral dosing compared to 27% and 1% in normal healthy subjects

Connecting to other gene-expression datasets Using GSEA, sets of genes reported to change with COPD-related phenotypes or with TGF treatment in other gene-expression studies were examined in a ranked list of genes ordered from most induced in severe emphysema to most repressed in severe emphysema by the t-statistic of the Lm coefficient in the linear mixed-effects model

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doi: 10.1007/s13679-023-00515-2

In the past, the Schilling test was used, but is rarely conducted today because this test uses radioactive B12