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The tests measure byproducts in the body that come from breaking down the drug, so they cannot detect how much of the drug is circulating in the body

Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome

doi:10.1089/jmf.2011.0320 Oranuba E, Deng H, Peng J, Dawsey SM, Kamangar F

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Supporting a dominant role for diet composition in establishing the Firmicutes : Bacteroidetes ratio, previous work has shown that mice maintained on a high-fat diet had a similar cecal Firmicutes : Bacteroidetes ratio to those maintained on a high-carbohydrate diet 77