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doi: 10.1038/s41575-019-0250-7

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Obesity and metabolic syndrome are significant contributors, with 54% of symptomatic patients under 30 showing elevated cholesterol and triglyceride levels

In the context of liquid biopsy, biomarkers reflecting peripheral iron homeostasissuch as CSF ferritin and the serum sTfR/ferritin ratiohave demonstrated high sensitivity and specificity in distinguishing mild cognitive impairment (MCI) from AD (Du et al., 2024)