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Investigational studies have been conducted to examine the profile of NMN supplementation in cardiovascular research contexts, with early data suggesting a potential role in cardiovascular biology without significant adverse effects reported

Food supplements should not be used as a substitute for a balanced and varied diet and a healthy lifestyle

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Lipoxygenases enzymatically oxidize PUFAs, leading to lethal lipid peroxidation and cell death ( ) is essential for glutathione synthesis, and its dysfunction exacerbates ferroptosis by impairing cystine uptake ( ROS are central to ferroptosis, as they drive lipid peroxidation

The competition between arginase and eNOS for their common substrate L-arginine impairs NO-mediated vasodilation (20)

PP is the editorial board member of Cellular & Molecular Immunology, but he has not been involved in the peer review or the decision-making of the article