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EBioMedicine 2 , 10901101 (2015)

Although both 5-Aza and DAC have significantly improved the management of hematological tumors, these first-generation hypomethylating agents are rapidly hydrolyzed in aqueous acidic or basic conditions, resulting in poor bioavailability and limited half-life

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doi: 10.1016/j.bbrc.2016.11.017 131 SuzukiT.HeaneyL

Phlebitis may be more likely if the same vein is used repeatedly for intravenous access, and can eventually develop into a hard cord which is unsuitable for IV access