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Further to this, some mice were fed on a diet that had the effect of inhibiting protein-arginine deiminase 4 (involved in NET formation), or metoprolol (involved in neutrophil migration)

Additionally, capecitabine is well known to cause hand-foot syndrome (palmar-plantar erythrodysesthesia) , which, although classified dermatologically, shares mechanistic overlap with GI toxicity due to the drugs activation in high perfusion areas

Seek urgent care if you experience severe symptoms, blood glucose above 300 mg/dL, or signs of infection

PMID: 40601845

Erythropoiesis-stimulating agents in the treatment of anaemia in cancer patients: ESMO Clinical Practice Guidelines for use