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Patients should review all their medications with their healthcare provider, as concomitant medicines (including SGLT2 inhibitors, diuretics, or caffeine-containing products) may contribute to increased urination

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For example, curcumin has been evaluated in Phase II clinical studies in pancreatic cancer and colorectal cancer patients, where oral doses up to 8 g/day demonstrated acceptable safety but limited systemic exposure, highlighting pharmacokinetic challenges

Le glutathion rduit (GSH), sous forme libre, peut facilement se dgrader dans lestomac cause du pH acide et de laction des enzymes, ce qui rend son absorption difficile et limite son usage