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Chronic estrogen treatment has been demonstrated to have a central effect in rats by enhancing the expression of neuronal NO synthase, which plays a role in the inhibitory regulation of brainstem sympathetic outflow (117, 128)

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Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., Tomeno, W., Imajo, K., Fujita, K., Yoneda, M., Kataoka, K., Taguri, M., Yamanaka, T., Seko, Y., Tanaka, S., Saito, S., Ono, M., Oeda, S., Eguchi, Y., Aoi, W., Nakajima, A

Herein, we distinguish between classical signaling pathways and metabolic pathways by defining the former as those predominantly involving non-metabolic enzymes

J Perinat Med 42:379384 Furukawa S, Sameshima H, Yang L, Harishkumar M, Ikenoue T (2014) Regional differences of microglial accumulation within 72 h of hypoxia-ischemia and the effect of acetylcholine receptor agonist on brain damage and microglial activation in newborn rats

Therefore, monitoring ALP levels through regular blood tests can help doctors detect any potential bone metastases early on and provide appropriate treatment options accordingly