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the 20 mg treatment group experienced a -5.0 kg reduction in body weight

Liu, X., Yamada, N., Maruyama, W

One possibility is that AMPK potentiates, albeit indirectly, the GAP activity of TSC2 towards Rheb, converting Rheb to its inactive, GDP-bound form that causes reductions in cell size and enhanced cell survival in the face of glucose deprivation [24]