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Many consistent alterations in the microbiome lead toward a causative or contributory role, and early interventions of microbiota could influence the progression of the disease and the severity of its symptoms

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4 and 11) had diabetes mellitus and were taking related medications, and 1 patient (No

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Further studies focused on new effector cell subsets, novel antibodies and ADC, besides those listed in Table 3 , and combination of drugs with immunotherapeutic tools may open new avenues to fight this tumor