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10.1038/s41598-018-29770-3 425 YuH.YangC.JianL.GuoS.ChenR.LiK.et al

Existing stealth strategies (hyaluronic acid coating) improve pharmacokinetics but still need enhancement in triggered exposure efficiency within the tumor microenvironment

Deregulated Signal Transduction Protein kinases and phosphatases are critical components of intracellular signaling that regulate cellular function, and acrolein is reported to inactivate as well as activate them in a contextual manner, depending on dose and cell type

This process, known as beiging, converts white fat cells into cells capable of burning energy as heat rather than storing it

In PCOS patients, hyperphosphorylation of serine residues ( e.g ., Ser307, Ser636) on IRS-1/2 suppresses their tyrosine phosphorylation, thereby impairing the downstream PI3K/AKT signaling pathway