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Mehlen, P., & Puisieux, A

Agathisflavone has been found to significantly increase the number of neuronal progenitor cells and mature neurons without increasing astrocytes or microglia, and also to effectively reduce the inflammatory factors factor-, interleukin-6, interleukin-1, NO, and PGE2 ( in vitro and enhances the neuroprotective properties of microglia and astrocytes

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Han M, Jeong S, Song J, Park SJ, Min Lee C, Lee K, et al

Meanwhile, HIF-1 increases the transcription of SLC7A11 and HO-1, which both protect from ferroptosis through decreasing ROS and increasing GSH (Feng et al