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All samples (FLAG-PRMT1-binding protein) were analyzed on an UltiMate 3000 RSLCnano system coupled online with Q Exactive HF mass spectrometer through a Nanospray Flex ion source (Thermo Fisher Scientific)

Icariin demonstrates a protective effect against gentamicin-induced ototoxicity in HEI-OC1 cells and cochlear explants through AMPK-SIRT3 signaling cascade activation, thereby offering a novel approach for addressing ototoxicity resulting from aminoglycoside antibiotics (Hu and Ma 2021)