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Increased circulating AGEs can accumulate in the renal glomeruli and enhance collagen and laminin production in the extracellular matrix together with proximal tubular senescence, oxidative stress, and inflammatory processes 66

These properties may support recovery from intense training , surgery, or illness

This dual role promotes orderly matrix remodeling

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Our present review discusses the breadth of prior research on immunometabolism in T2D to comprehend how neutrophil function is altered due to the reprogramming of metabolic pathways in diabetic conditions and to highlight therapeutic approaches to ameliorate aberrant neutrophil activity (Fig