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Additionally, in the proposed rule, CMS did not initially consider various circumstances that may prevent an OTP from being able to perform SDOH risk assessments at intake, which commenters highlighted

Scenario 2: significantly past expiration Medication that is weeks or months past expiration has had considerably more time for degradation

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The rodent model of postoperative ileus by Venkova et al., 2009 used exactly this dose window and showed a dose-dependent acceleration of gastric emptying