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Extended treatment continued to limit body weight gain and white adipose tissue mass, lowered total plasma cholesterol, and showed measurable accumulation in adipose tissue consistent with the compounds lipophilic profile

it's a potent non-stimulant small molecule that selectively inhibits Nicotinamide N-methyltransferase (NNMT), an enzyme primarily found in adipose tissue and the liver

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B-12 support B-12 injections can support patients who are appropriate candidates for vitamin B-12 supplementation

Selected Preclinical Findings NNMT knockdown protects against DIO via increased energy expenditure and remodeled polyamine flux