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The absence of CRY has been hypothesized to release its inhibition on cAMP production, thereby increasing cAMP levels and PKA activation and, subsequently, PKA-mediated phosphorylation of the p65 subunit of NF-B, leading to its constitutive activation

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Subsequently, research on retinal nanomedicine involving nanoagent-based therapy is highlighted, with an emphasis on intelligent theranostic contrast agents derived from versatile nanomaterials for the tracking, imaging, diagnosis, and treatment of retinal diseases

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