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The above studies suggest that cuproptosis involves a copper-triggered mode of mitochondrial cell death, challenging the conventional view that oxidative stress is the underlying molecular mechanism of metal-induced toxicity, thus reinforcing the view that mitochondria are multifaceted regulators of cell death ( FIGURE 1 5 SAW and mitochondrial dysfunction SAW is primarily characterized by skeletal muscle atrophy and weakness, often affecting skeletal and respiratory muscles, and in severe cases, it can lead to quadriplegia (Wai et al., 2015

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