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Description

J Pharmacol Exp Ther 1990;254: 521-7

doi:10.1093/ageing/afg109

Specifications Storage & Handling Lyophilized ARA-290 should be stored at -20 C in a desiccated environment away from direct light

These cytokines not only amplify local inflammation but also further disrupt the System Xc GSHGPX4 axis and upregulate ACSL4 in neighboring tubular cells, creating a ferroptosis-inflammatory cascade that expands tubular injury

More significantly, M1 macrophages also elevate the ROS concentration via the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) pathway (63)