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The positive anti-tumor effects of SAHA notwithstanding, it is crucial to highlight the elevated toxicity observed with high doses of the drug, resulting in adverse effects like fatigue, diarrhea, anorexia, dehydration, myelosuppression, thrombocytopenia, among others (Mrakovcic et al., 2017)

Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8

CGI-C of much improved or very much improved was achieved in 26% of patients on placebo, 28% receiving 12 mg/day, 49% receiving 24 mg/day, and 44% on 36 mg/day