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Consequently, this initiates the activation of subsequent signaling routes linked to c-MET, including RAS/MAPK, PI3K/AKT, Wnt/-catenin, and JAK/STAT [3,4,5]

although, the effect of the MOR agonist desensitizes and produces heterologous desensitization of KOR responses (KOR responses do not desensitize independent of MOR activation) (Chen et al., 2015)