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Zimmermann R et al

Furthermore, Nrf2 activators reduce the extent of neuronal death caused by iron overload, most likely by regulating genes associated with iron metabolism and the synthesis of antioxidants that protect cells from oxidative stress and ferroptosis [48, 49]

doi:10.1371/journal.pone.0264575

This pattern supports the interpretation of decreased C2 levels as a potential trait marker indexing an underlying vulnerability for the development of depression, in line with previous genetic analyses [32]