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The annual medical expenditure for DED in the United States is approximately $ 3.8 billion, imposing a huge economic burden on society [2]

Enhanced carbon dioxide leads to a modied diurnal rhythm of nitrate reductase activity in older plants, and a large stimulation of nitrate reductase activity and higher levels of amino acids in young tobacco plants

Molecular Metabolism, 46 , Article 101090

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Cold stress can produce an increase in the amount of ROS, such as H 2 O 2

The absence of direct functional roles during catalysis for the GT1 domain is consistent with previous hypotheses derived from chimeric studies of GLT25D1/COLGALT1 and the CERCAM inactive paralog 34 , and is further supported by the absence of the essential negatively charged amino acid side chains near the galactose moiety of the UDP--Gal donor substrate (Fig