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Nat Cell Biol (2020) 22:41224

Varadharajan et al

Safety concerns also arise, with potential adverse effects including muscle contractions, tissue damage, pain, and inflammation during therapy, underscoring the need for enhanced safety protocols

Synovial fluid from patients with late-stage OA who were undergoing knee joint replacement had a lower level of oxidoreductases than that from healthy controls 87

Source These microbiota inhabit the gastrointestinal tract, which offers a large but vulnerable surface to house their ecosystem

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