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Community sources also disagree on route, splitting between oral capsules and transdermal application in a DMSO carrier

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doi: 10.3390/nu13010247 63 MinY.SunT.NiuZ.LiuF

[7] Yamamoto et al researched the frequency of occurrence as related to the treatment timeline, finding that the reaction will most commonly occur during the initial loading dose (61%), that a smaller fraction will occur over the next four hours (37%), and that the least frequent fraction occurs during the terminal taper (2%)

You would then apply the cream as directed