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54 At the early stages of the cell life cycle, excessive iron can cause DNA damage and mutations, cell cycle disorders, and tumorigenesis

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The C-terminus residue and its side chains interact with R289 and N345, respectively

The reaction was carried out with 110 M enzyme, 0100 M GTP in 20 mM HEPES buffer, pH 6.8, 150 mM NaCl, 10 mM MgCl 2

doi: 10.1042/BJ20100409 65 DiotalleviM.ChecconiP.PalamaraA

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