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Although the clinical efficacy of vitamin B 6 and its effect on decreasing plasma total homocysteine are well established, the underlying mechanism is still unclear

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[CrossRef] [Google Scholar] Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation

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Proc Natl Acad Sci USA (2005) 102(25):905661

Instead, the disease and context specific loss or disruption of astrocyte functions can result in the accumulation of various potentially toxic metabolites or in the loss of support functions for neurones or synapses or in (the deadliest) combination of both