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While lipid accumulation has multiple effects on cellular signaling, 3 major lipid-associated inhibitory phosphorylation events on the insulin signaling pathway include (a) acylglycerol-induced pIR at T1150 (human T1160) (22), (b) fatty acidinduced pIRS1 at S1097 (human S1101) (23), and (c) ER stressmediated pJNK (24)

Artusi et al., 2025), a critical and systematic analysis of the methodologies employed to generate these data is still lacking

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Unlike some adhesion molecules, P-selectin is not present on resting platelets or endothelial cells [58], which minimizes unintended interactions with NPs and preserves normal cellular function

The nonclinical and clinical studies reported to date indicate that they could be predictive of the severity of APAP-induced injury, especially when measured in conjunction with other transcriptomics and proteomics biomarkers as well as the standard parameters

10.3389/fphys.2023.1237741 7 AlvesM