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PDT has been studied since the 1980s (268, 269), and has shown promising efficacy in many glioma preclinical studies (270272)

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(2012) 7:e36216

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These observations demonstrate that individual proteins can undergo simultaneous lactylation and acetylation modifications, potentially generating synergistic effects

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Fat and Water Soluble Because ALA operates in both fat-soluble and water-soluble environments, it provides antioxidant protection in cell membranes, blood plasma, brain tissue, and peripheral nerves simultaneously

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Heme produces signaling molecules, such as CO, biliverdin (BV), BR and Fe 2+ , through the catalysis of HO-1

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Afterwards, viability, cell surface antigen and intracellular cytokine staining was performed as described above

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