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In case of the transporter-mediated prodrug approach, the rational design of prodrugs should take into account the functional expression and structural requirements for substrate binding and translocation via the transporter, as well as capability to be bioconverted by an enzyme at the target site (74)

Studies were conducted to test the decorporation efficacy of ReadiSorb toward Co-60 in male Fisher F344 rats over a 5-day period

Intranasal GSH has been formally studied only in Parkinsons disease (PD), a disease characterized by early glutathione depletion

113 Thus, through the coordinated activation of GSH production, utilization, and regeneration, Nrf2 ensures maintenance of the intracellular levels of reduced GSH