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Major depressive disorder: hypothesis, mechanism, prevention and treatment Signal Transduction and Targeted Therapy The application of antidepressant drugs in cancer treatment ScienceDirect Paxil Withdrawal Symptoms, Timeline, and Support Klonopin Withdrawal Orthomolecular Management of Symptoms Microglia Targeted Nanotherapeutics in Major Depressive Disorder: An Integrative Perspective on Neuroinflammation and Drug Delivery Frontiers Advances of paeoniflorin in depression: the molecular mechanism and formula application

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Per the preclinical safety profile, this remains far below any dose associated with toxicity in animals 1

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Subfamilies and isoforms can be categorized based on the sequence similarity, domain architecture, quaternary structure, enzymatic activity, ironsulfur cluster binding and the number of active site cysteine residues 1,2,3,4,5