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for a typical schedule), and fall rapidly toward morning as light inhibits further synthesis

In one sentence, the mechanism is receptor-mediated: GHRP binding to GHS-R1a activates a Gq/11-coupled phospholipase C cascade that mobilises intracellular calcium and triggers exocytosis of stored GH from the anterior pituitary, independent of hypothalamic GHRH signalling

However, GSAAT(C190S) accumulated to a lesser extent than any of the other mutants, albeit still more than that expressed in the gsa2 mutant

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