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Although efficacy for anti-TNF agents has been proven, up to 30% of patients have no clinical improvement after initiation of anti-TNF therapy (primary nonresponse), and up to 50% of patients lose response over time (secondary nonresponse) [173]

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There must be no associated disease, and this pattern must be persistent for a minimum of 4 weeks

Case presentation The patient is a 76-year-old female who was admitted to the US hospital with severe pancytopenia found at her primary care physician's (PCP) office

Zielinski MR, Gibbons AJ

Together with human AKAP11 KO iNeuron, we conducted quantitative mass spectrometry-based proteomics (Tandem Mass Tag (TMT) and Data-independent Acquisition (DIA)) 20,21,22 and analyzed the changes of proteins and cellular pathways in neurons from mutant mouse brains and iNeurons compared to control neurons