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The molecular regulators of metabolic reprogramming, which are crucial for developing novel therapeutic strategies, however, remain largely unknown

Mccormack WP, Hoffman JR, Pruna GJ, Jajtner AR, Townsend JR, Stout JR, Fragala MS, Fukuda DH

doi:10.1111/j.1749-6632.1975.tb25349.x

Following co-incubation, the cells were harvested, washed with PBS, and stained with an anti-CD11c-APC antibody for 30 min at 4 C in the dark

3.4 The functional significance of alternative programmed cell death modalities in oncogenesis and therapeutic interventions Programmed cell death, a genetically regulated active cellular termination process, plays an essential role in the development and maintenance of homeostasis in multicellular organisms and can be classified into apoptotic and non-apoptotic modalities

This interaction typically leads to translational repression and/or mRNA decay, with the relative contribution of each mechanism varying by cellular context and the degree of complementarity